Provided by – Gyeonggi-do
Human Ace Co., Ltd. (CEO Ko Seong-ho) introduced a new drug development solution that can replace animal testing when developing new drugs through the YouTube channel of Pangyo Techno Valley, a global convergence R&D hub cluster centered on global IT, BT, CT, and NT.
Developing a new drug takes 10 to 15 years, costs about 5 trillion won, and has a very low success rate of only 1 in 10,000 attempts. In addition, existing drug toxicity tests using 2D cell culture are conducted in environments that are different from actual biological structures, and drug toxicity evaluations using animal tests have limitations due to differences between species.
To overcome these limitations, Human Ace is developing ▲Heart-on-a-chip ▲Liver-on chip for low-cost, rapid and accurate evaluation of new drug toxicity and efficacy based on human stem cell-derived cardiomyocytes. -a-chip) ▲Developed a brain simulation chip (Brain-on-a-chip).
Cardiotoxicity evaluation of all candidate substances is an important evaluation item that must be performed when developing new drugs, and Human Ace’s heart simulation chip is a human stem chip that mimics the major microstructure of the heart to overcome the limitations of existing 2D cell culture and animal testing. It is a heart simulation chip based on cell-derived cardiomyocytes.
Its strength is that it can increase the consistency with clinical results when assessing the toxicity of new drug candidates and increases the probability of success in drug development by omitting multiple trials.
The chips, which mimic the heart’s main microorganism, studied tissue cells from various organs differentiated from human stem cells to avoid animal testing when testing new drugs. For example, take the heart by creating a micro environment that is important in the heart, making it into a chip, inserting cardiomyocytes differentiated from stem cells into it, and adding drug candidates from the medium. You can take a cardiac toxicity test.
Seongho Ko, CEO of Human Ace, said, “Our organ simulation chip is a 3D biological tissue chip that mimics the main microstructure of human organs and can replace animal testing in evaluating the toxicity and efficacy of new drug candidates.” He added, “The liver simulation chip and Following the brain simulation chip, we are planning to create a cancer-on-a-chip in the future to research antibiotics. “The ultimate goal is a human-on-a-chip where everything is connected,” he said.
Source: Pangyo Techno Valley Official Newsroom
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